Electrochemical Metabolic Profiling Reveals Mitochondrial Hyperactivation and Enhanced Neural Progenitor Proliferation in MLC1-Mutant Human Cortical Organoids
Kyeong‐Mo Koo, Jeong‐Sun Choi, Yun-kyeong Nam, Hyung Joo Kim, Chang‐Dae Kim, Soo-Hwan Jeong, Hyun‐Jong Jang, Kayeong Lim, Byung-Chan Lim, Tae-Hyung Kim, Kyung‐Ok Cho
The paper uses cortical organoids to show MLC1 mutations cause mitochondrial hyperactivation and increased neural progenitor proliferation.
bioRxiv · Apr 16, 2025 · PreprintNeuroscience