Kayeong Lim

Electrochemical Metabolic Profiling Reveals Mitochondrial Hyperactivation and Enhanced Neural Progenitor Proliferation in MLC1-Mutant Human Cortical Organoids

The paper uses cortical organoids to show MLC1 mutations cause mitochondrial hyperactivation and increased neural progenitor proliferation.

Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice

This study shows that an enhancer mutation in MEF2C causes mitochondrial dysfunction and motor deficits in mice by impairing mitochondria-encoded gene expression.

Efficient DNA base editing via an optimized DYW-like deaminase

This paper introduces SsCBE, a CRISPR-based cytosine base editor with improved efficiency, specificity, and reduced cytotoxicity, enabling targeted edits in mouse zygotes and mitochondrial DNA.

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA

The paper engineers TALE-linked deaminases to reduce off-target edits in mtDNA editing, resulting in mice with Leigh disease mutations and reduced heart rates.

Web-based design and analysis tools for CRISPR base editing

The paper introduces two web tools, BE-Designer and BE-Analyzer, for designing CRISPR base editor targets and analyzing next-generation sequencing data.