Ligand-Specified Signaling Efficacy Defined by Unique Transitions in G Protein Conformations
Xudong Wang, Sun Wenkai, Nathaniel Hays, Pangche Wang, Cheng Zhang, C Zhang, Libin Ye
This study quantifies Gs protein conformational transitions in response to different ligands, revealing ligand-specific dynamics that determine GPCR signaling efficacy.
bioRxiv · Jul 25, 2026 · PreprintBiophysics