Sun Wenkai

This paper introduces a novel 19F-labeled probe, BTMB, for studying GPCR conformational dynamics and demonstrates its advantages over existing probes through molecular dynamics simulations.

This study quantifies Gs protein conformational transitions in response to different ligands, revealing ligand-specific dynamics that determine GPCR signaling efficacy.

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.