Cheng Zhang

Mechanism of GPR84 allosteric modulation at a helix 8-proximate site

This paper identifies a helix 8-proximate allosteric site in GPR84 and shows how it enables Gi-biased signalling through structural and dynamic mechanisms.

Steric control of signaling bias in the immunometabolic receptor GPR84

The paper identifies ligands with varying steric profiles that exhibit different β-arrestin recruitment capacities at GPR84, revealing a mechanism for controlling signaling bias.

Ligand-Specified Signaling Efficacy Defined by Unique Transitions in G Protein Conformations

This study quantifies Gs protein conformational transitions in response to different ligands, revealing ligand-specific dynamics that determine GPCR signaling efficacy.

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

The paper reports the structures of D1R-Gs complex bound to dopamine and LY3154207, revealing mechanisms of dopamine recognition and allosteric modulation for drug discovery.