A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease
K. S. Yang, S.-T. A. Kuo, L. R. Blankenship, Y. J. Sheng, B. Sankaran, P. Li, C. A. Fierkee, D. H. Russell, X. Yan, S. Xu, W. R. Liu
The paper identifies a novel Y-shaped crosslink in SARS-CoV-2 MPro that acts as a redox switch, regulating its catalytic activity and offering new targets for antiviral drug development.
bioRxiv · Apr 29, 2022 · PreprintBiochemistry