Author

Y. J. Sheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

K. S. Yang· 3 shared S. Xu· 3 shared W. R. Liu· 3 shared B. Sankaran· 2 shared C. A. Fierke· 2 shared L. R. Blankenship· 2 shared P. Li· 2 shared Y. R. Alugubelli· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

K. S. Yang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

J. S. Morse, Y. J. Sheng, J. T. Hampton, L. D. Sylvain, S. Das, Y. R. Alugubelli, P.-H. C. Chen, K. S. Yang, S. Xu, C. A. Fierke, W. R. Liu

This paper develops PADLE, a phage-assisted method to evolve potent HDAC8 inhibitors, identifying two highly selective and potent inhibitors with sub-nanomolar Ki values.

bioRxiv · Sep 14, 2022Biochemistry

A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease

K. S. Yang, S.-T. A. Kuo, L. R. Blankenship, Y. J. Sheng, B. Sankaran, P. Li, C. A. Fierkee, D. H. Russell, X. Yan, S. Xu, W. R. Liu

The paper identifies a novel Y-shaped crosslink in SARS-CoV-2 MPro that acts as a redox switch, regulating its catalytic activity and offering new targets for antiviral drug development.

bioRxiv · Apr 29, 2022 · PreprintBiochemistry

A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors

W. R. Liu, K. S. Yang, X. R. Ma, Y. Ma, Y. R. Alugubelli, D. A. Scott, E. C. Vatansever, A. K. Drelich, Z. Z. Geng, L. R. Blankenship, B. Sankaran, H. E. Ward, Y. J. Sheng, J. C. Hsu, K. K. Kratch, , H. S. Hayatshahi

This study designs and synthesizes potent SARS-CoV-2 main protease inhibitors, with some showing IC50 values below 100 nM and high virus inhibition potency in cell assays.

bioRxiv · Jul 28, 2020 · PreprintBiochemistry