Inhibition of Acyl-CoA Synthetase Long Chain Isozymes Decreases Multiple Myeloma Cell Proliferation and Causes Mitochondrial Dysfunction
C. S. Murphy, V. E. DeMambro, S. Fadel, H. Fairfield, C. A. Garter, P. Rodriguez, Y.-W. Qiang, C. P. H. Vary, M. R. Reagan
This study shows that inhibiting ACSLs in multiple myeloma cells reduces proliferation and causes mitochondrial dysfunction, suggesting ACSLs as potential therapeutic targets.
bioRxiv · Mar 13, 2024Cancer Biology