Development of fluorescent peptide G Protein Coupled Receptor activation biosensors for NanoBRET characterisation of intracellular allosteric modulators
J. P. Farmer, S. N. Mistry, C. A. Laughton, N. D. Holliday
This paper develops fluorescent peptide biosensors for NanoBRET-based assessment of GPCR intracellular allosteric modulator (IAM) interactions, demonstrating their utility in affinity screening and receptor activation studies.
bioRxiv · May 30, 2022 · PreprintPharmacology & Toxicology