Glioblastoma mutations impair ligand discrimination by EGFR
C. Hu, C. A. Leche, A. Kiyatkin, S. E. Stayrook, K. M. Ferguson, M. A. Lemmon
This study shows that GBM mutations in EGFR disrupt ligand discrimination by altering dimer structure and stability, leading to aberrant signaling.
bioRxiv · May 4, 2021 · PreprintBiochemistry