Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis
D. L. Matera, K. M. DiLillo, M. R. Smith, C. D. Davidson, R. Parikh, M. Said, C. A. Wilke, I. M. Lombaert, K. B. Arnold, B. B. Moore, B. M. Baker
This study uses 3D hydrogels to show that matrix degradation, not stiffness, drives myofibroblast differentiation in IPF, contrasting with 2D findings.
bioRxiv · Jun 2, 2020Bioengineering