M. Said

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles

The paper designs nanomolar binders for diverse small molecules using a pseudocycle-based shape complementarity method, enabling direct conversion into sensing systems.

Molecular Epidemiology of multidrug-resistant Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli outbreak among neonates in Tembisa Hospital, South Africa

The paper investigates an outbreak of multidrug-resistant bacteria in a neonatal ward, identifying clonal and plasmid-mediated spread of resistance genes.

A novel injectable radiopaque hydrogel with potent properties for multicolor CT imaging in the context of brain and cartilage regenerative therapy

This paper develops an iodine-labeled hydrogel for multicolor CT imaging to monitor cell and hydrogel distribution in vivo for regenerative therapy.

IMPDH1 retinal variants control filament architecture to tune allosteric regulation

The paper shows IMPDH1 retinal variants form different filaments that affect GTP regulation, with disease mutations disrupting or not affecting this regulation.

Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in idiopathic pulmonary fibrosis

This study uses 3D hydrogels to show that matrix degradation, not stiffness, drives myofibroblast differentiation in IPF, contrasting with 2D findings.

Antimicrobial susceptibility and serotype distribution of Streptococcus agalactiae recto-vaginal colonizing isolates from pregnant women at a tertiary hospital in Pretoria, South Africa: an observational descriptive study letter

This study examines serotype distribution and antimicrobial susceptibility of GBS isolates from pregnant women, finding high penicillin susceptibility and resistance patterns affecting macrolides.