Author

C. Barin-Le Guellec

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Janaszkiewicz· 2 shared A. Toth· 2 shared F. Di Meo· 2 shared P. Marquet· 2 shared Q. Faucher· 2 shared B. Chantemargue· 1 shared H. Arnion· 1 shared M. Martin· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Janaszkiewicz

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2 papers

Recent·Most cited

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale

A. Janaszkiewicz, A. Toth, Q. Faucher, H. Arnion, N. Vedrenne, C. Barin-Le Guellec, P. Marquet, F. Di Meo

This study investigates the structure and function of hOAT1 using molecular dynamics simulations, identifying substrate binding sites and allosteric mechanisms involving lipid interactions.

bioRxiv · Jul 14, 2022Pharmacology & Toxicology

Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes

A. Janaszkiewicz, A. Toth, Q. Faucher, M. Martin, B. Chantemargue, C. Barin-Le Guellec, P. Marquet, F. Di Meo

This study presents the first robust model of hOAT1 in outward-facing conformation using protein-threading and MD simulations, revealing structural and functional insights into its transport mechanism.

Scientific Reports · Apr 29, 2022Peer-reviewedPharmacology & Toxicology