Structural basis for the allosteric regulation of Human Topoisomerase 2α
A. Vanden Broeck, C. Lotz, R. Drillien, C. Bedez, V. Lamour
This study presents cryo-EM structures of human Top2 nucleoprotein complexes, revealing molecular details of allosteric regulation and the role of the C-terminal domain.
bioRxiv · Aug 23, 2020Biochemistry