Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitors
M. K. Rathinaswamy, Z. Gaieb, K. D. Fleming, C. Borsari, N. J. Harris, B. J. Moeller, M. P. Wymann, R. E. Amaro, J. E. Burke
This study investigates how mutations in PI3Kγ affect its regulatory dynamics and identifies a strategy for developing selective inhibitors.
bioRxiv · Dec 1, 2020Biochemistry