Author

C. C. Gradinaru

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Assay:protein structure· 3 Approach:statistical model· 3 Approach:deep learning· 2 Approach:Bayesian inference· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

G.-N. W. Gomes· 2 shared J. D. Forman-Kay· 2 shared T. E. Tsangaris· 2 shared Z. H. Liu· 2 shared A. Bah· 1 shared A. Malik· 1 shared A. Namini· 1 shared A. Orazietti· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

G.-N. W. Gomes

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4 papers

Recent·Most cited

Local Disordered Region Sampling (LDRS) for Ensemble Modeling of Proteins with Experimentally Undetermined or Low Confidence Prediction Segments

Z. H. Liu, J. M. C. Teixeira, O. Zhang, T. E. Tsangaris, J. Li, C. C. Gradinaru, T. Head-Gordon, J. D. Forman-Kay

The paper introduces LDRS, a tool for generating conformational ensembles of intrinsically disordered regions in proteins, improving structural modeling of flexible segments.

bioRxiv · Jul 25, 2023Biophysics

Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modelling and Clustering

T. E. Tsangaris, S. Smyth, G.-N. W. Gomes, Z. H. Liu, M. Milchberg, G. A. Wasney, A. Bah, J. D. Forman-Kay, C. C. Gradinaru

This study uses integrative modelling and clustering to analyze the structural propensities of 4E-BP2 in its non-phosphorylated and five-phosphorylated forms, revealing insights into intrachain interactions and conformational states.

bioRxiv · Jun 20, 2023 · PreprintBiophysics

Integrative conformational ensembles of Sic1 using different initial pools and optimization methods

G.-N. Gomes, A. Namini, C. C. Gradinaru

The paper compares conformational ensembles of Sic1 using different initial pools and optimization methods to improve structural characterization of disordered proteins.

bioRxiv · Apr 1, 2022Biophysics

Ligand Modulation of the Conformational Dynamics of the A2A Adenosine Receptor Revealed by Single-Molecule Fluorescence

D. D. Fernandes, C. Neale, G.-N. W. Gomes, Y. Li, A. Malik, A. Pandey, A. Orazietti, X. Wang, L. Ye, S. Prosser, C. C. Gradinaru

This study uses single-molecule fluorescence to analyze how ligands modulate conformational dynamics of the A2A adenosine receptor, revealing ligand-dependent changes in state transitions and dynamics.

bioRxiv · Sep 20, 2020Biophysics