J. D. Forman-Kay

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

This study shows PARP1 condensates partition DNA repair proteins and enhance DNA ligation through PARylation-dependent mechanisms.

Local Disordered Region Sampling (LDRS) for Ensemble Modeling of Proteins with Experimentally Undetermined or Low Confidence Prediction Segments

The paper introduces LDRS, a tool for generating conformational ensembles of intrinsically disordered regions in proteins, improving structural modeling of flexible segments.

Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modelling and Clustering

This study uses integrative modelling and clustering to analyze the structural propensities of 4E-BP2 in its non-phosphorylated and five-phosphorylated forms, revealing insights into intrachain interactions and conformational states.

Exploration of O-GlcNAc-transferase (OGT) glycosylation sites reveals a target sequence compositional bias

The paper identifies an amino acid compositional bias in OGT glycosylation sites by testing disordered protein regions and validating it through FUS modification and NMR experiments.

An interpretable machine learning algorithm to predict disordered protein phase separation based on biophysicalinteractions

The paper introduces LLPhyScore, a machine learning tool that predicts IDR-driven protein phase separation by analyzing biophysical interactions and provides interpretable feature contributions.

IDPConformerGenerator: A Flexible Software Suite for Sampling Conformational Space of Disordered Protein States

IDPConformerGenerator generates diverse ensembles of disordered protein states using physical restraints and machine learning, enabling structural analysis of intrinsically disordered proteins.

Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2

This paper shows AlphaFold2 can predict structures of conditionally folded intrinsically disordered regions with high precision, revealing their prevalence in human and prokaryotic proteins and their association with disease mutations.

Multisite Phosphorylation and Binding Alter Conformational Dynamics of the 4E-BP2 Protein

This study uses single-molecule techniques to analyze how phosphorylation and binding alter the conformational dynamics of the intrinsically disordered 4E-BP2 protein.

O-GlcNAcylation reduces phase separation and aggregation of the EWS N-terminal low complexity region

Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

The paper identifies molecular features in intrinsically disordered protein regions that predict functional roles and validates their importance in mitochondrial targeting.