Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue Models
C. Campana, E. Ricci, C. Bartolucci, S. Severi, E. A. Sobie
This study uses mathematical modeling to show that intercellular coupling and cellular heterogeneity protect the sinoatrial node from ionic perturbations in both healthy and diseased conditions.
bioRxiv · Apr 14, 2022Physiology