Author

E. A. Sobie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:electrophysiology· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. Iyengar· 3 shared B. Hu· 2 shared D. M. Gonzalez· 2 shared D. Vidovic· 2 shared E. U. Azeloglu· 2 shared G. Jayaraman· 2 shared J. Goldfarb· 2 shared J. Hansen· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

R. Iyengar

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Author profile →

5 papers

Recent·Most cited

Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments

J. Yang, N. Daily, T. K. Pullinger, T. Wakatsuki, E. A. Sobie

This paper develops a computational pipeline to calibrate iPSC-CM electrophysiological models using optical experiments, improving parameter estimates and model predictions of unseen responses.

bioRxiv · Jan 7, 2024Pharmacology & Toxicology

Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue Models

C. Campana, E. Ricci, C. Bartolucci, S. Severi, E. A. Sobie

This study uses mathematical modeling to show that intercellular coupling and cellular heterogeneity protect the sinoatrial node from ionic perturbations in both healthy and diseased conditions.

bioRxiv · Apr 14, 2022Physiology

PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

N. M. Wickramasinghe, D. Sachs, B. Shewale, D. M. Gonzalez, P. Dhanan-Krishnan, D. Torre, E. LaMarca, S. Raimo, R. Dariolli, M. Serasinghe, J. Mayourian, R. Sebra, K. G. Beaumont, R. Iyengar, D. L. French, , N. C. Dubois

This study shows that activating PPARD signaling enhances metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

bioRxiv · Jul 12, 2021 · PreprintCell Biology

A Library Of Induced Pluripotent Stem Cells From Clinically Well-Characterized, Diverse Healthy Human Individuals

C. Schaniel, P. Dhanan, B. Hu, Y. Xiong, T. Raghunandan, D. M. Gonzalez, S. L. D'Souza, A. Yadaw, J. Hansen, G. Jayaraman, B. Mathew, M. Machado, S. Berger, J. Tripodi, V. Najfeld, , R. Iyengar

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

bioRxiv · Oct 29, 2020Cell Biology

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset

Y. Xiong, T. Liu, T. Chen, J. Hansen, B. Hu, Y. Chen, G. Jayaraman, S. Schürer, D. Vidovic, J. Goldfarb, E. A. Sobie, M. R. Birtwistle, R. Iyengar, H. Li, E. U. Azeloglu

The paper generates proteomic signatures of kinase inhibitor-induced cardiotoxicity using high-throughput proteomics and integrates them with transcriptomic data to predict drug toxicity.

bioRxiv · Feb 26, 2020 · PreprintPharmacology & Toxicology