Epilepsy-associated Mutations in the Calcium-sensing Receptor Disrupt the Regulation of NALCN Sodium-leak Channel by Extracellular Calcium in Neurons
This study shows that CaSR mutations linked to epilepsy disrupt CaSR's regulation of NALCN sodium-leak channels in neurons, affecting neuronal excitability.
bioRxiv · Nov 7, 2020 · PreprintPhysiology