System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells
L. Wigger, C. Casals Casas, M. Baruchet, K. B. Trang, S. Pradervand, A. Naldi, B. Desvergne
The paper analyzes the cross-talk between nuclear receptors LXR, FXR, and PPAR in HepaRG liver cells, revealing opposite effects of FXR and LXR on cell cycle regulation and hepatocyte differentiation.
bioRxiv · Mar 25, 2019Physiology