Novel Analgesic Agents Obtained by Molecular Hybridization of Orthosteric and Allosteric Ligands
C. Matera, L. Flammini, F. Riefolo, G. Domenichini, M. De Amici, E. Barocelli, C. Dallanoce, S. Bertoni
The paper develops novel analgesic agents through molecular hybridization of orthosteric and allosteric muscarinic ligands and evaluates their efficacy and tolerability in mice.
bioRxiv · Dec 5, 2019Pharmacology & Toxicology