C. F. Maurice

The dietary ellagitannin metabolite urolithin A is produced by a molybdenum-dependent dehydroxylase encoded by prevalent human gut Enterocloster spp.

The paper identifies Enterocloster spp. and the ucd operon as key producers of urolithin A from dietary ellagitannins using multi-omics approaches.

Dextran sodium sulfate-induced colitis alters the proportion and composition of replicating gut bacteria

This study uses single-cell techniques and metagenomics to analyze gut bacterial replication dynamics in a colitis model, showing reduced replication proportion during inflammation and changes in bacterial composition.

Actively replicating gut bacteria identified by 5-ethynyl-2'-deoxyuridine (EdU) click chemistry and cell sorting

This study uses EdU-click and FACS-Seq to identify actively replicating gut bacteria in human and murine samples, revealing Ileibacterium as resistant to antibiotic perturbations.

Bacteriophages Playing Nice: Lysogenic bacteriophage replication stable in the human gut microbiota

The paper analyzes phage dynamics in the human gut using longitudinal sequencing data, showing that prophage induction occurs spontaneously and maintains phage stability.

Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates severity of DSS-colitis

This study shows that transplanting bacteriophages from UC patients alters gut bacteria and worsens colitis in mice.

Translational activity is uncoupled from nucleic acid content in bacterial cells of the human gut microbiota

The paper uses BONCAT and FACS-Seq to identify translationally active bacteria in the gut microbiota and finds they are not distinct from the whole community, while high nucleic acid content bacteria are distinct and correlate with damaged cells.