A. Reyes

HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoids.

This study develops microglia-containing cerebral organoids (CO-iMs) to model HIV-1 infection and its effects on neuroinflammation and neuronal function.

ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates

The paper identifies ZNF574 as a key factor in a quality control pathway that degrades defective ribosome intermediates in human cells.

Apobec-Mediated Retroviral Hypermutation In Vivo is Dependent on Mouse Strain

This study shows that Rem protein in B6 mice affects tumorigenesis independently of Apobec-mediated proviral hypermutation, with TBLV-SD causing more tumors than TBLV-WT.

Ontogeny of the organized nasopharynx-associated lymphoid tissue in rainbow trout

This study identifies the developmental sequence of organized nasopharynx-associated lymphoid tissue (O-NALT) in rainbow trout, showing CD8+ T cells initiate its formation and that O-NALT is fully formed by 1400DD, marking a potential earliest time for effective mucosal vaccination.

Structural basis of TFIIIC-dependent RNA Polymerase III transcription initiation

The paper uses cryo-EM and smFRET to study the structure and dynamics of the TFIIIA-TFIIIC complex bound to the 5S rRNA promoter, revealing DNA bending and dissociation during transcription initiation.

Reprograming human fibroblasts into Sertoli cells: a tool for personalized medicine

This paper reprograms human fibroblasts into Sertoli cells to improve diagnosis of Disorders of Sex Development by creating a model that mimics embryonic gonadal development.

Bacteriophages Playing Nice: Lysogenic bacteriophage replication stable in the human gut microbiota

The paper analyzes phage dynamics in the human gut using longitudinal sequencing data, showing that prophage induction occurs spontaneously and maintains phage stability.

Data-driven polymer model for mechanistic exploration of diploid genome organization

The paper introduces a data-driven polymer model to study diploid genome organization, validated against Hi-C data and showing chromosome positioning principles.

Computational search for UV radiation resistance strategies in Deinococcus swuensis isolated from Paramo ecosystems.

This study identifies genes and non-coding RNAs involved in UV resistance in Deinococcus swuensis using RNA-seq and differential expression analysis.

FINE GRAINED LONGITUDINAL ANALYSIS OF COCOA BEAN FERMENTATION PROVIDES INSIGHTS INTO THE DYNAMICS OF MICROBIAL POPULATIONS

The paper analyzes microbial population dynamics during cocoa bean fermentation in two Colombian regions, identifying dominant strains and their role in fermentation quality.

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

This study investigates the origin, evolution, and epidemiology of crAssphage, a widespread human gut virus, using global DNA sequences showing local phylogeographic clustering and ancient primate associations.

The virome in adult monozygotic twins with concordant or discordant gut microbiomes

This study examines the relationship between microbiome diversity and virome diversity in adult monozygotic twins, finding that microbiome discordance correlates with virome dissimilarity.

Intercellular communication via the comX-Inducing Peptide (XIP) of Streptococcus mutans

This study demonstrates that XIP from Streptococcus mutans functions as an intercellular signal, showing diffusibility and signaling without cell-to-cell contact, with cell lysis enhancing its release.