Exploring the evolutionary history of kinetic stability in the alpha-lytic protease family
C. F. Nixon, S. A. Lim, Z. R. Sailer, I. N. Zheludev, C. L. Gee, B. A. Kelch, M. J. Harms, S. Marqusee
This study investigates how sequence variation in the alpha-lytic protease family relates to kinetic stability and energy landscapes, finding that pro-region size and specific amino acids influence folding speed and stability.
bioRxiv · Aug 30, 2020Biophysics