Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
C. Nixon, S. A. Lim, M. Sternke, D. Barrick, M. J. Harms, S. Marqusee
The paper compares consensus and ancestral protein reconstruction methods using Ribonuclease H sequences, finding that phylogenetically restricted consensus proteins are more stable than those from diverse clades.
bioRxiv · Jun 29, 2023Biophysics
S. A. Lim, J. Zhou, A. J. Martinko, Y.-H. Wang, E. V. Filippova, V. Steri, D. Wang, S. G. Remesh, J. Liu, B. Hann, A. A. Kossiakoff, M. J. Evans, K. K. Leung, J. A. Wells
The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.
bioRxiv · Jun 14, 2021 · PreprintBiochemistry
A. J. Samelson, Q. D. Tran, R. Robinot, L. Carrau, V. V. Rezelj, A. Mac Kain, M. Chen, G. N. Ramadoss, X. Guo, S. A. Lim, I. Lui, J. Nunez, S. J. Rockwood, J. Wang, N. Liu, , M. Kampmann
This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.
bioRxiv · Jan 19, 2021Cell Biology
C. F. Nixon, S. A. Lim, Z. R. Sailer, I. N. Zheludev, C. L. Gee, B. A. Kelch, M. J. Harms, S. Marqusee
This study investigates how sequence variation in the alpha-lytic protease family relates to kinetic stability and energy landscapes, finding that pro-region size and specific amino acids influence folding speed and stability.
bioRxiv · Aug 30, 2020Biophysics
C. J. Bracken, S. A. Lim, P. Solomon, N. J. Rettko, D. P. Nguyen, B. S. Zha, K. Schaefer, J. R. Byrnes, J. Zhou, I. Lui, J. Liu, K. Pance, QCRG Structural Biology Consortium, X. X. Zhou, K. K. Leung, J. A. Wells
This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.
bioRxiv · Aug 8, 2020 · PreprintBioengineering
A. Glasgow, J. E. Glasgow, D. Limonta, P. Solomon, I. Lui, Y. Zhang, M. A. Nix, N. J. Rettko, S. A. Lim, S. Zha, R. Yamin, K. Kao, O. S. Rosenberg, J. V. Ravetch, A. P. Wiita, , J. A. Wells
This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.
bioRxiv · Jul 31, 2020Bioengineering
I. Lui, X. X. Zhou, S. A. Lim, S. Elledge, P. Solomon, N. J. Rettko, B. S. Zha, L. L. Kirkemo, J. A. Gramespacher, J. Liu, F. Muecksch, J. C. C. Lorenzi, F. Schmidt, Y. Weisblum, D. F. Robbiani, , J. A. Wells
This study investigates the interaction between SARS-CoV-2 Spike and ACE2, showing that dimeric ACE2 binds with high affinity to Spike and blocks viral entry, with limited intra-Spike avidity.
bioRxiv · May 21, 2020 · PreprintBiochemistry
L. Srinivasan, R. Khilnani, P. Fung, M. Low, U. Esquivel, B. White, G. Sidhu, J. Rangel, S. A. Lim, L. S. Sudhof, J. O. Aleman
This paper introduces a menstrual blood-based HbA1c test for prediabetes screening, showing it is comparable to venous HbA1c and preferred by users for regular testing.
bioRxiv · Sep 5, 2019 · PreprintPathology
S. A. Lim, E. R. Bolin, S. Marqusee
This study uses ancestral sequence reconstruction and hydrogen exchange to trace the folding pathway of RNase H across evolutionary time, finding conserved intermediates but divergent pathways.
bioRxiv · May 30, 2018Biochemistry