C. Giurgiu

Kinetic Explanations for the Sequence Biases Observed in the Nonenzymatic Copying of RNA Templates

The paper investigates nonenzymatic RNA copying using 2AI-bridged dinucleotides, finding that sequence-dependent differences in binding and reaction rates limit template copying.

Non-enzymatic primer extension with strand displacement

This study demonstrates non-enzymatic RNA primer extension through strand displacement using short RNA oligonucleotides, suggesting a prebiotic mechanism for RNA replication.

Prebiotically Plausible ‘Patching’ of RNA Backbone Cleavage Through a 3′-5′ Pyrophosphate Linkage

This study demonstrates that 3′-phosphate terminated RNA strands can participate in template-directed copying reactions to form stable pyrophosphate linkages, offering a non-enzymatic pathway for RNA strand recovery.