The cellular Notch1 Protein Promotes KSHV reactivation in an Rta-dependent manner.
J. DeCotiis-Mauro, S. M. Han, H. Mello, C. Goyeneche, G. Marchesini-Tovar, L. Jin, V. Bellofatto, D. M. Lukac
This study shows that constitutive Notch activity is required for KSHV reactivation, with Notch1 promoting viral production through interactions with Rta and RBP-Jk.
bioRxiv · Oct 21, 2022Microbiology