Silencing of oncogenic KRAS by mutant-selective small interfering RNA
B. Papke, S. H. Azam, A. Y. Feng, A. E. D. Van Swearingen, C. Gutierrez-Ford, P. S. Pallan, M. Egli, A. D. Cox, C. J. Der, C. V. Pecot
This study develops a mutant-selective siRNA, EFTX-D1, that targets KRAS mutations in codons 12 and 13, reducing mutant KRAS expression and impairing cancer cell proliferation.
bioRxiv · Oct 8, 2020Cancer Biology