Engineered Reversible Inhibition of SpyCatcher Reactivity Enables Rapid Generation of Bispecific Antibodies
C. Hentrich, M. Putyrski, H. Hanuschka, W. Preis, S.-J. Kellmann, M. Wich, M. Cavada, S. Hanselka, F. Ylera
This paper introduces SpyLock, a reversibly inhibitable SpyCatcher variant, enabling the rapid generation of bispecific antibodies through a two-step ligation process.
bioRxiv · Oct 27, 2023Biochemistry