DNA damaged-induced phosphorylation of a viral replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function
T. Melendy, C. Homiski, R. Dey-Rao, S. Shen, J. Qu
This study shows DDR phosphorylation of SV40 LT at T518 inhibits DNA replication by reducing helicase activity without affecting ATPase function or protein interactions.
bioRxiv · Sep 29, 2023 · PreprintMicrobiology