Proteomics analysis reveals novel phosphorylated residues and associated proteins of the polyomavirus DNA replication initiation complex.
R. Dey-Rao, S. Shen, J. Qu, T. Melendy
bioRxiv · Feb 8, 2024 · PreprintMicrobiology
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T. Melendy
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2021-2024 · peak 1/yrCo-Author Collaboration Network
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DNA damaged-induced phosphorylation of a viral replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function
T. Melendy, C. Homiski, R. Dey-Rao, S. Shen, J. Qu
This study shows DDR phosphorylation of SV40 LT at T518 inhibits DNA replication by reducing helicase activity without affecting ATPase function or protein interactions.
bioRxiv · Sep 29, 2023 · PreprintMicrobiology
DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma
J. C. Martin, A. Gupta, T. J. Hagoel, L. Gao, M. L. Lynch, A. Woloszynska, T. Melendy, J. Kane, J. Kuechle, J. Ohm
This study shows that DDK inhibition causes replication stress and mitotic catastrophe in Ewing sarcoma cells, reducing viability and suggesting DDK as a therapeutic target.
bioRxiv · Nov 2, 2021 · PreprintCancer Biology