Author

C. I. Lynch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. S. Walker· 1 shared D. Adlard· 1 shared D. W. Crook· 1 shared G. P. Morlock· 1 shared J. Carter· 1 shared J. Crain· 1 shared J. E. Posey· 1 shared L. X. Phan· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

A. S. Walker

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Author profile →

2 papers

Recent·Most cited

Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches.

J. Carter, T. M. Walker, A. S. Walker, M. Whitfield, G. P. Morlock, C. I. Lynch, D. Adlard, T. E. Peto, J. E. Posey, D. W. Crook, P. W. Fowler

This paper predicts pyrazinamide resistance in Mycobacterium tuberculosis using machine learning models trained on pncA mutations and structural features, achieving 80.2% sensitivity and 76.9% specificity.

bioRxiv · Nov 14, 2023 · PreprintMicrobiology

Influence of effective polarization on ion and water interactions within a biomimetic nanopore

L. X. Phan, C. I. Lynch, J. Crain, M. Sansom, S. J. Tucker

This study investigates ion and water interactions in a biomimetic nanopore using MD simulations with and without polarization effects, finding that polarization significantly influences ion behavior at hydrophobic interfaces.

bioRxiv · Dec 10, 2021Biophysics