Author

T. M. Walker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:whole-genome sequencing· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Research Focus:variant calling· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Assay:imaging· 2

Frequent Co-Authors

D. W. Crook· 6 shared T. E. Peto· 5 shared P. W. Fowler· 4 shared A. L. Gibertoni Cruz· 3 shared A. S. Walker· 3 shared Z. Iqbal· 3 shared D. M. Cirillo· 2 shared E. Borroni· 2 shared

Activity by Year

2016-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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6 shared papersMicrobiology

D. W. Crook

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches.

J. Carter, T. M. Walker, A. S. Walker, M. Whitfield, G. P. Morlock, C. I. Lynch, D. Adlard, T. E. Peto, J. E. Posey, D. W. Crook, P. W. Fowler

This paper predicts pyrazinamide resistance in Mycobacterium tuberculosis using machine learning models trained on pncA mutations and structural features, achieving 80.2% sensitivity and 76.9% specificity.

bioRxiv · Nov 14, 2023 · PreprintMicrobiology

Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination and Drug Susceptibility Prediction

K. Nilgiriwala, M.-S. Rabodoarivelo, M. B. Hall, G. Patel, A. Mandal, S. Mishra, F. R. Andrianomanana, K. Dingle, G. Rodger, S. George, D. W. Crook, S. Hoosdally, N. Mistry, N. Rakotosamimanana, Z. Iqbal, , T. M. Walker

This study evaluates direct-from-sputum whole-genome sequencing for tuberculosis diagnosis, lineage determination, and drug susceptibility prediction using different sequencing technologies.

bioRxiv · Oct 31, 2022Microbiology

Distribution and origins of Mycobacterium tuberculosis L4 in Southeast Asia

P. M. Ashton, J. Cha, C. Anscombe, N. T. T. Thuong, G. E. Thwaites, T. M. Walker

The paper investigates the distribution of Mycobacterium tuberculosis Lineage 4 in Southeast Asia using genomic data, finding that most L4 sub-clades in the region have no recent European origin and may involve China as an intermediate.

bioRxiv · Aug 1, 2022Microbiology

BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.

P. W. Fowler, C. Wright, H. Spiers, T. Zhu, E. M. Baeten, S. W. Hoosdally, A. L. Gibertoni Cruz, A. Roohi, S. Kouchaki, T. M. Walker, T. E. Peto, G. Miller, C. Lintott, D. Clifton, D. W. Crook, , The CRyPTIC Consortium

BashTheBug uses crowdsourced volunteers to accurately measure MICs of 13 antitubercular drugs from microdilution plates, showing median/mode of classifications is sufficient.

bioRxiv · Jul 20, 2021Microbiology

Validating a 14-drug microtitre plate containing bedaquiline and delamanid for large-scale research susceptibility testing of Mycobacterium tuberculosis

P. M. Rancoita, F. Cugnata, A. L. Gibertoni Cruz, E. Borroni, S. J. Hoosdally, T. M. Walker, C. Grazian, T. J. Davies, T. E. Peto, D. W. Crook, P. W. Fowler, D. M. Cirillo, the CRyPTIC Consortium

The paper validates a 14-drug microtitre plate for measuring MICs of anti-TB compounds in M. tuberculosis isolates, finding optimal reading with the Vizion system after 14 days incubation.

bioRxiv · Jun 15, 2018Microbiology

Automated detection of bacterial growth on 96-well plates for high-throughput drug susceptibility testing of Mycobacterium tuberculosis

P. W. Fowler, A. L. Gibertoni Cruz, S. J. Hoosdally, L. Jarrett, E. Borroni, M. Chiacchiaretta, P. Rathod, T. M. Walker, E. Robinson, T. E. Peto, D. M. Cirillo, E. G. Smith, D. W. Crook

This paper introduces AMyGDA, a software tool for automated detection of M. tuberculosis growth on 96-well plates to determine drug susceptibility.

bioRxiv · Jun 15, 2018Microbiology

A novel multi SNP based method for the identification of subspecies and associated lineages and sub-lineages of the Mycobacterium tuberculosis complex by whole genome sequencing

S. I. W. Lipworth, R. Jajou, H. de Neeling, P. Bradley, W. van der Hoek, G. Maphalala, M. Bonnet, E. Sanchez-Padilla, R. Diel, S. Niemann, Z. Iqbal, G. Smith, T. Peto, D. Crook, T. M. Walker, D. van Soolingen

This paper introduces SNP-IT, a method using whole genome sequencing to identify subspecies and lineages of Mycobacterium tuberculosis complex, revealing high prevalence of M. orygis in UK clinical isolates.

bioRxiv · Jan 5, 2018Microbiology

Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples.

A. A. Votintseva, P. Bradley, L. Pankhurst, C. del Ojo Elias, M. Loose, K. Nilgiriwala, A. Chatterjee, E. G. Smith, N. Sanderson, T. M. Walker, M. R. Morgan, D. H. Wyllie, A. S. Walker, T. E. Peto, D. W. Crook, Z. Iqbal

This paper develops a low-cost WGS method for TB diagnosis and surveillance using direct respiratory samples, achieving rapid results with high concordance with reference labs.

bioRxiv · Dec 19, 2016Microbiology