Protein kinase Cϵ activation induces EHD-dependent degradation and downregulation of KATP channels: Implications for glucose stimulated insulin secretion
C. J. Cockcroft, P. Manna, R. Karnik, T. Taneja, D. Wrighton, J. T. Mankouri, H. Rong, A. Sivaprasadarao
This study shows that PKCε activates EHD-dependent lysosomal degradation of KATP channels, contributing to glucose-stimulated insulin secretion through ATP-independent mechanisms.
bioRxiv · Jan 15, 2020 · PreprintCell Biology