A. Sivaprasadarao

A distinct signalling circuit upregulates cytotoxic ROS production in a cellular model of Parkinsons disease: key roles for TRPM2, Zn2+ and complex III

The paper identifies a novel signalling circuit involving TRPM2, NOX2, Ca2+, Zn2+, and complex III that drives cytotoxic ROS production in Parkinson's disease.

Protein kinase Cϵ activation induces EHD-dependent degradation and downregulation of KATP channels: Implications for glucose stimulated insulin secretion

This study shows that PKCε activates EHD-dependent lysosomal degradation of KATP channels, contributing to glucose-stimulated insulin secretion through ATP-independent mechanisms.

Piezo1 channel agonist mimics high glucose as a stimulator of insulin release

This study shows that Piezo1 agonist Yoda1 stimulates insulin release from beta-cells and pancreatic islets, suggesting Piezo1's role in cell swelling-induced insulin secretion.