Author

C. J. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 4 Approach:deep learning· 3 Research Focus:protein structure prediction· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:database / resource· 2 Approach:benchmark study· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. S. Richardson· 4 shared A. J. McCoy· 2 shared B. K. Poon· 2 shared D. C. Richardson· 2 shared P. D. Adams· 2 shared R. D. Oeffner· 2 shared R. J. Read· 2 shared T. C. Terwilliger· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiochemistry

J. S. Richardson

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Author profile →

5 papers

Recent·Most cited

AlphaFold predictions are valuable hypotheses, and accelerate but do not replace experimental structure determination

T. C. Terwilliger, D. L. Leibschner, T. Croll, C. J. Williams, A. J. McCoy, B. K. Poon, P. Afonine, R. D. Oeffner, J. S. Richardson, R. J. Read, P. D. Adams

The paper evaluates high-confidence AlphaFold predictions against experimental crystal structures, showing they are accurate but require experimental validation for detailed structural features.

bioRxiv · Nov 21, 2022Biochemistry

Accelerating crystal structure determination with iterative AlphaFold prediction

T. C. Terwilliger, P. V. Afonine, D. Liebschner, T. I. Croll, A. J. McCoy, R. D. Oeffner, C. J. Williams, B. K. Poon, J. S. Richardson, R. J. Read, P. D. Adams

This paper introduces an iterative AlphaFold method to accelerate crystal structure determination using sequence and crystallographic data, achieving higher accuracy than non-iterative approaches.

bioRxiv · Nov 18, 2022Biochemistry

The importance of residue-level filtering, and the Top2018 best-parts dataset of high-quality protein residues

C. J. Williams, D. C. Richardson, J. S. Richardson

The paper curates a high-quality protein residue dataset, demonstrating the benefits of residue-level filtering for structural bioinformatics.

bioRxiv · Oct 5, 2021Biochemistry

ER-Anchored Transcription Factors bZIP17 and bZIP60 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula

B. Ribeiro, M.-L. Erffelinck, M. Colinas, C. J. Williams, E. Van Hamme, E. Lacchini, R. De Clercq, M. Perassolo, A. Goossens

ER stress bZIP transcription factors interfere with jasmonate-inducible bHLH transcription factors to modulate plant specialized metabolism under stress.

bioRxiv · Jan 17, 2020 · PreprintPlant Biology

CaBLAM for CryoEM Chiropraxis, UnDowser to Rethink \"Waters\", and NGL Viewer to Recapture Online 3D Graphics in MolProbity Validation

M. G. Prisant, C. J. Williams, V. B. Chen, J. S. Richardson, D. C. Richardson

The paper introduces new validation tools for macromolecular models, addresses security and technical challenges in structural biology validation, and improves 3D visualization and water molecule analysis.

bioRxiv · Oct 7, 2019Biophysics