Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
Z. Ke, T. P. Peacock, J. C. Brown, C. M. Sheppard, T. I. Croll, A. Kotecha, D. H. Goldhill, W. S. Barclay, J. A. Briggs
The paper analyzes SARS-CoV-2 variant virion morphology and spike protein structures using cryo-EM, finding no adaptive changes in virion shape but multiple amino acid changes affecting spike conformational dynamics.
bioRxiv · Dec 21, 2023Microbiology
T. C. Terwilliger, P. V. Afonine, D. Liebschner, T. I. Croll, A. J. McCoy, R. D. Oeffner, C. J. Williams, B. K. Poon, J. S. Richardson, R. J. Read, P. D. Adams
This paper introduces an iterative AlphaFold method to accelerate crystal structure determination using sequence and crystallographic data, achieving higher accuracy than non-iterative approaches.
bioRxiv · Nov 18, 2022Biochemistry
T. C. Terwilliger, B. K. Poon, P. Afonine, C. J. Schlicksup, T. I. Croll, C. Millan-Nebot, J. S. Richardson, R. J. Read, P. D. Adams
The paper improves AlphaFold modeling by incorporating experimental density maps iteratively, resulting in more accurate protein structure predictions.
bioRxiv · Jan 7, 2022Biochemistry
M. Akdel, D. E. Pires, E. Porta-Pardo, J. Janes, A. O. Zalevsky, B. Meszaros, P. Bryant, L. L. Good, R. A. Laskowski, G. Pozzati, A. Shenoy, W. Zhu, P. Kundrotas, V. Ruiz-Serra, C. H. Rodrigues, , P. Beltrao
This study assesses AlphaFold 2's applications in structural biology, finding it outperforms existing tools in predicting disorder, complexes, and structural features with high confidence.
bioRxiv · Sep 26, 2021 · PreprintBiophysics
Q. Liu, D. Yang, Y. Zhuang, T. I. Croll, X. Cai, A. Dai, X. He, J. Duan, W. Yin, C. Ye, F. Zhou, B. Wu, Q. Zhao, H. E. Xu, M.-W. Wang, Y. Jiang
The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.
bioRxiv · May 9, 2021 · PreprintBiophysics
T. N. Starr, N. Czudnochowski, F. Zatta, Y.-J. Park, Z. Liu, A. Addetia, D. Pinto, M. Beltramello, P. Hernandez, A. J. Greaney, R. Marzi, W. G. Glass, I. Zhang, A. S. Dingens, J. E. Bowen, , Veesler
This study identifies antibodies against SARS-CoV-2 that balance neutralization potency and breadth, with some showing high resistance to viral escape.
bioRxiv · Apr 6, 2021 · PreprintMicrobiology
Y. Jiang, F. Zhou, C. Ye, X. Ma, W. Yin, Q. Zhou, X. He, X. Zhang, T. I. Croll, D. Yang, P. Wang, H. E. Xu, M.-W. Wang
The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.
Cell Research · Mar 19, 2021Peer-reviewedBiophysics
Y. K. Choi, Y. Cao, M. Frank, H. Woo, S.-J. Park, M. S. Yeom, T. I. Croll, C. Seok, W. Im
This study uses molecular dynamics simulations to analyze the structure, dynamics, and antibody binding of the fully-glycosylated SARS-CoV-2 spike protein, revealing key roles of glycans in stabilizing RBD conformations and antibody epitope exposure.
bioRxiv · Oct 18, 2020Biophysics
The paper introduces two new adaptive restraint potentials for model rebuilding in molecular modeling, demonstrating their implementation in ISOLDE and applications in real-world examples.
bioRxiv · Sep 29, 2020Biophysics
H. Woo, S.-J. Park, Y. K. Choi, T. Park, M. Tanveer, Y. Cao, N. R. Kern, J. Lee, M. S. Yeom, T. I. Croll, C. Seok, W. Im
The paper models and simulates a fully-glycosylated SARS-CoV-2 spike protein in a viral membrane using computational methods and provides the structures for research on COVID-19 prevention and treatment.
bioRxiv · May 20, 2020Biophysics
C. Gao, M. A. Pallett, T. I. Croll, G. L. Smith, S. C. Graham
This study identifies the molecular mechanism by which vaccinia virus protein A55 subverts the Cul3 ubiquitin ligase, showing high-affinity binding and structural similarity to cellular BTB-Kelch proteins.
bioRxiv · Nov 5, 2018Biochemistry