Temporal Effects of Galactose and Manganese Supplementation on Monoclonal Antibody N-Linked Glycosylation in Fed-Batch and Perfusion Bioreactor Operation
A. Gyorgypal, E. Fratz-Berilla, C. Kohnhorst, D. N. Powers, S. P. S. Chundawat
This study examines how galactose and manganese supplementation affects Trastuzumab N-glycosylation over time in fed-batch and perfusion bioreactors, showing temporal changes in glycoform composition.
bioRxiv · Apr 15, 2023 · PreprintBiochemistry