Engineered chimeras unveil swappable modular features of fatty acid and polyketide synthase acyl carrier proteins
Y. I. Cho, C. L. Armstrong, A. Sulpizio, K. K. Acheampong, K. N. Banks, O. Bardhan, S. J. Churchill, A. E. Connolly-Sporing, C. E. W. Crawford, P. L. Cruz Parrilla, S. M. Curtis, L. M. De La Ossa, S. C. Epstein, C. J. Farrehi, G. S. Hamrick, , L. K. Charkoudian
This study designs chimeric acyl carrier proteins to swap modular features between different ACPs, enabling compatibility with specific enzymes for synthetic pathway engineering.
bioRxiv · Dec 30, 2021Biochemistry