Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
F. Hoyt, P. Alam, E. Artikis, C. L. Schwartz, A. G. Hughson, B. Race, C. Baune, G. J. Raymond, G. S. Baron, A. Kraus, B. Caughey
The paper determines the near-atomic structure of two prion strains from the same host genotype, revealing conformational differences that underlie strain-specific characteristics.
bioRxiv · Sep 19, 2022Biophysics