P. Alam

Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice

This study shows that genetic silencing of KCa3.1 reduces atherosclerosis in ApoE null mice by decreasing lesion size and macrophage content.

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

Mode III tear resistance of Bombyx mori silk cocoons

This paper examines the tear resistance of Bombyx mori silk cocoons, finding that tear strength increases from innermost to outermost layers and correlates with porosity and fibre mobility.

Drug repurposing screens identifies compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions

Cryo-EM of prion strains from the same genotype of host identifies conformational determinants

The paper determines the near-atomic structure of two prion strains from the same host genotype, revealing conformational differences that underlie strain-specific characteristics.

Cytoplasmic membrane thinning observed by interfacial dyes is likely a common effect of bactericidal antibiotics

The paper uses membrane-specific dyes to measure antibiotic-induced membrane damage in E. coli and ESKAPE pathogens, finding that cytoplasmic membrane thinning correlates with bactericidal antibiotic sensitivity.

Polarized α-synuclein trafficking and transcytosis across Brain Endothelial Cells via Rab7-decorated carriers

This study identifies Rab7-decorated carriers mediating polarized transcytosis of monomeric α-synuclein across brain endothelial cells, suggesting Rab7 as a therapeutic target for Parkinson's disease.

Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning

This paper uses structure-based machine learning to identify potent small molecule inhibitors of α-synuclein aggregation, achieving compounds two orders of magnitude more potent than previous reports.

Adipocyte deletion of the RNA binding protein HuR induces cardiac hypertrophy and fibrosis

This study shows that deleting HuR in adipose tissue causes cardiac hypertrophy and fibrosis, likely through inflammation and vesicle transport changes in subcutaneous white adipose tissue.