Analysis of the 4q35 chromatin organization reveals distinct long-range interactions in patients affected with Facio-Scapulo-Humeral Dystrophy.
M.-C. Gaillard, N. Broucqsault, J. Morere, C. Laberthonniere, C. Dion, C. Badja, S. Roche, K. Nguyen, F. Magdinier, J. Robin
This study examines the 3D chromatin organization of the 4q35 locus in FSHD patients, finding that D4Z4 contractions and SMCHD1 mutations alter spatial gene interactions and expression.
bioRxiv · Dec 7, 2018Cell Biology