K. Nguyen

Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

Multi-Omics after O-GlcNAc Alteration Identifies Cellular Processes Working Synergistically to Promote Aneuploidy

The paper uses multi-omics analysis to show OGT regulates aneuploidy by fine-tuning multiple cellular pathways through O-GlcNAcylation.

A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice

B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters

The paper identifies B cells as drivers of T cell immunosenescence and aging, showing that targeting B cells with CD20 antibodies can reverse age-related T cell dysfunction.

Difference in Kernel Shape and Endocarp Anatomy Promote Dehiscence in Pistachio Endocarp

This study identifies anatomical and morphological traits in pistachio endocarp that contribute to shell dehiscence, showing that cell shape specialization and kernel width influence split rate.

Labile assembly of a tardigrade protein induces biostasis

This study identifies a mechanism by which tardigrade CAHS D proteins form gels to protect cells during desiccation, showing that gelation reduces molecular motion and metabolic activity, with reversible effects.

Machine Learning Classification of Alzheimer's Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal Subregions

Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding

This paper develops a method for analyzing bivalent analyte binding kinetics in high-throughput SPR data, improving parameter estimation and identifiability through grid search and profile likelihood analysis.

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state

This study shows that natural and engineered desiccation-tolerant mediators can stabilize Human Blood Clotting Factor VIII without cold-chain storage.

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

Transparent and stretchable metal nanowire composite recording microelectrode arrays

This paper develops stretchable, transparent microelectrode arrays using gold-coated silver nanowires, demonstrating high optical transparency, low impedance, and stable performance for biomedical applications.

Kinetic and Thermodynamic Insights on Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET assay

The paper introduces a new NanoBRET assay to study agonist interactions with PTHR1, revealing kinetic and thermodynamic insights into ligand binding and activation.

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) recruits CoREST transcription repressor complexes to silence HIV following proviral reactivation in microglial cells

This study shows that Nurr1 agonists enhance HIV silencing in microglial cells by recruiting CoREST repressor complexes to the HIV promoter, promoting latency and reducing neuroinflammation.

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

This study identifies two macrophage populations driving inflammation in the lower airway during SARS-CoV-2 infection in rhesus macaques and shows baricitinib effectively reduces their influx and cytokine production.

Network analysis outlines strengths and weaknesses of emerging SARS-CoV-2 Spike variants

The paper uses network analysis of SARS-CoV-2 Spike protein variants to identify critical residues and assess the impact of mutations on protein function and adaptation.

Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and disease.

This paper identifies a conserved RNA structure in influenza A virus that mediates packaging and disease, showing that targeting it inhibits virus production and reduces disease severity.

Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

This paper investigates the effect of inhibiting the H3K27 demethylase UTX on HIV-1 latency, finding that it enhances epigenetic silencing but does not provide permanent suppression.

The SARS-CoV-2 Spike Variant D614G Favors an Open Conformational State

This study shows the D614G mutation in SARS-CoV-2 Spike protein increases open conformations, enhancing infectivity and neutralization sensitivity.

Exploring the role of glycans in the interaction of SARS-CoV-2 RBD and human receptor ACE2

This study uses molecular simulations to analyze how different glycan types on SARS-CoV-2 RBD and ACE2 affect their binding, finding that glycan presence does not alter the contact signature but influences binding affinity.

Feeding Experimentation Device version 3 (FED3): An open-source home-cage compatible device for measuring food intake and operant behavior

The paper introduces FED3, an open-source device for measuring food intake and operant behavior in rodents, demonstrating its utility in quantifying intake, meal patterns, and operant learning across multiple institutions.

Inferring number of populations and changes in connectivity under the n-island model

The paper infers population structure and connectivity changes using the n-island model and IICR curves from PSMC data, finding ancient human population structure.

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

This paper develops a feeder-free organoid culture system for human distal lung progenitors and demonstrates SARS-CoV-2 infection of club cells in a novel in vitro model.

Quantifying Color Vision Changes Associated with Cataracts Using Cone Contrast Thresholds

This study quantifies color vision changes in cataract patients and aging individuals using cone contrast thresholds, finding age-related declines in S-cone sensitivity and improvements post-surgery.

Two-Photon Microperimetry: A media opacity-independent retinal function assay

This study evaluates 2-photon infrared microperimetry for assessing retinal function in patients with optical media opacities, finding it provides more consistent results than visible light methods.

A meta-analysis reveals temperature, dose, life stage, and taxonomy influence host susceptibility to a fungal parasite

This study meta-analyzes 58 amphibian-Bd infection experiments to show temperature, dose, life stage, and taxonomy influence host mortality.

High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methods

This paper introduces Digital Spatial Profiling (DSP), a method for high-plex spatial analysis of proteins and RNA in tissue, and demonstrates its application in studying immune and cancer microenvironments.

Analysis of the 4q35 chromatin organization reveals distinct long-range interactions in patients affected with Facio-Scapulo-Humeral Dystrophy.

This study examines the 3D chromatin organization of the 4q35 locus in FSHD patients, finding that D4Z4 contractions and SMCHD1 mutations alter spatial gene interactions and expression.

Impacts of thermal mismatches on chytrid fungus Batrachochytrium dendrobatidis prevalence are moderated by life stage, body size, elevation and latitude

The paper examines how thermal mismatches affect Bd infection prevalence in amphibians, finding that larger hosts and lower-latitude hosts are more susceptible under temperature mismatches.

The hyperstability and composition of Giardias ventral disc highlights the remarkable versatility of microtubule organelles

The paper identifies 54 new disc-associated proteins in Giardia's ventral disc and shows its hyperstable microtubule array is stabilized by novel and conserved proteins.

Robust and stable transcriptional repression in Giardia using CRISPRi

This study develops CRISPRi for stable transcriptional repression in Giardia, demonstrating efficient gene knockdown and phenotypic effects.