Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair
J. J. Kathiriya, C. Wang, A. Brumwell, M. Cassandras, C. Le Saux, P. Wolters, M. Matthay, H. A. Chapman, T. Peng
This study shows human alveolar type 2 cells can transdifferentiate into KRT5+ basal cells in 3D organoids, a process linked to IPF pathology and not observed in murine cells.
bioRxiv · Jun 6, 2020 · PreprintCell Biology