Author

H. A. Chapman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Brumwell· 2 shared J. J. Kathiriya· 2 shared A. N. Brumwell· 1 shared B. J. Backes· 1 shared C. J. Le Saux· 1 shared C. Le Saux· 1 shared C. Wang· 1 shared D. Sheppard· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

A. Brumwell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A fibroblast-derived TGFβ/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

M. L. Cohen, A. N. Brumwell, T. C. Ho, G. Montas, J. A. Golden, K. D. Jones, P. J. Wolters, Y. Wei, H. A. Chapman, C. J. Le Saux

bioRxiv · Aug 2, 2023 · PreprintCell Biology

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

V. C. Auyeung, M. S. Downey, J. J. Kathiriya, M. Thamsen, T. A. Wenger, B. J. Backes, A. Brumwell, H. A. Chapman, D. Sheppard, F. R. Papa

This study shows that IRE1α inhibition reduces ER stress and TGFβ signaling in lung epithelial cells, decreasing fibrosis by targeting damage-associated progenitors.

bioRxiv · Sep 16, 2021Cell Biology

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair

J. J. Kathiriya, C. Wang, A. Brumwell, M. Cassandras, C. Le Saux, P. Wolters, M. Matthay, H. A. Chapman, T. Peng

This study shows human alveolar type 2 cells can transdifferentiate into KRT5+ basal cells in 3D organoids, a process linked to IPF pathology and not observed in murine cells.

bioRxiv · Jun 6, 2020 · PreprintCell Biology