Author

A. Brumwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. A. Chapman· 2 shared J. J. Kathiriya· 2 shared A. Koromilas· 1 shared B. J. Backes· 1 shared B.-J. Guan· 1 shared C. Le Saux· 1 shared C. Patsis· 1 shared C. Wang· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

H. A. Chapman

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Author profile →

3 papers

Recent·Most cited

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

V. C. Auyeung, M. S. Downey, J. J. Kathiriya, M. Thamsen, T. A. Wenger, B. J. Backes, A. Brumwell, H. A. Chapman, D. Sheppard, F. R. Papa

This study shows that IRE1α inhibition reduces ER stress and TGFβ signaling in lung epithelial cells, decreasing fibrosis by targeting damage-associated progenitors.

bioRxiv · Sep 16, 2021Cell Biology

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair

J. J. Kathiriya, C. Wang, A. Brumwell, M. Cassandras, C. Le Saux, P. Wolters, M. Matthay, H. A. Chapman, T. Peng

This study shows human alveolar type 2 cells can transdifferentiate into KRT5+ basal cells in 3D organoids, a process linked to IPF pathology and not observed in murine cells.

bioRxiv · Jun 6, 2020 · PreprintCell Biology

Translational control of breast cancer plasticity

M. Jewer, L. Lee, G. Zhang, J. Liu, S. D. Findlay, K. M. Vincent, K. Tandoc, D. Dieters-Castator, D. F. Quail, I. Dutta, M. Coatham, Z. Xu, B.-J. Guan, M. Hatzoglou, A. Brumwell, , L.-M. Postovit

The paper identifies hypoxia and drug-induced translational activation of NANOG, SNAIL, and NODAL isoforms that drive breast cancer plasticity and stem-cell-like phenotypes, with potential therapeutic implications.

bioRxiv · Apr 2, 2019Cancer Biology