DNA damage primes hematopoietic stem cells for direct megakaryopoiesis
C. M. Garyn, O. Bover, J. W. Murray, M. Jing, K. Salas-Briceno, S. R. Ross, H.-W. Snoeck
This study shows DNA damage and G2 phase arrest induce direct megakaryopoiesis from HSCs through a post-transcriptional mechanism, while impairing HSC maintenance.
bioRxiv · May 13, 2023 · PreprintCell Biology