S. R. Ross

Murine leukemia virus can infect non-dividing primary cells

This study shows MLV can infect non-dividing primary dendritic cells, challenging the belief that gammaretroviruses require cell division for nuclear entry.

DNA damage primes hematopoietic stem cells for direct megakaryopoiesis

This study shows DNA damage and G2 phase arrest induce direct megakaryopoiesis from HSCs through a post-transcriptional mechanism, while impairing HSC maintenance.

IFI207, a young and fast-evolving antiviral factor, stabilizes STING

The paper identifies IFI207 as a rapidly evolving antiviral factor that stabilizes STING, enhancing the host's response to viral infections.

Repair of APOBEC3G-mutated retroviral DNA in vivo is facilitated by the host enzyme uracil DNA glycosylase 2

This study shows that uracil DNA glycosylase 2 (UNG) repairs APOBEC3G-induced mutations in retroviral DNA in vivo, reducing G-to-A mutations and limiting viral integration.

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

Human APOBEC3G prevents emergence of infectious endogenous retrovirus in mice

This study shows that human APOBEC3G prevents the emergence of infectious endogenous retroviruses in mice, demonstrating its in vivo antiviral activity against ERVs.

DDX41 recognizes RNA/DNA retroviral reverse transcripts and is critical for in vivo control of MLV infection

This study identifies DDX41 as a sensor for retroviral RNA/DNA hybrids and shows its critical role in controlling MLV infection in vivo, alongside cGAS.