The oxysterol synthesizing enzyme CH25H contributes to the development of intestinal fibrosis
T. Raselli, A. Wyss, M. N. Gonzalez Alvarado, B. Weder, C. Mamie, M. R. Spalinger, W. T. van Haaften, G. Dijkstra, A. W. Sailer, P. H. Imenez Silva, C. A. Wagner, V. Tosevski, S. Leibl, M. Scharl, G. Rogler, , B. Misselwitz
This study shows that the oxysterol synthesizing enzyme CH25H contributes to intestinal fibrosis in Crohn's disease by promoting collagen deposition and fibroblast activity.
bioRxiv · Sep 23, 2018 · PreprintImmunology